L-Tyrosine , Reference Substance , CAS 60-18-4 , reference standard preparation 98% HPLC / Whatsapp:+8615308670259

Basic Info

CAS NO. 60-18-4

Classification: Food Additives

Appearance: Powder

Description: White Crystals or Crystalline Power

Loss on Drying: 0.3%Max

Chloride: 0.04%Max

Iron: 0.003%Max

Assay: 98.5-101.5%

Transport Package: 25kg/Drum

Origin: China

Efficacy: Feed Additives

Type: L-Tyrosine

Color: White

Specific Rotation: -9.8°~-11.2°

Residue on Ignition: 0.4%Max

Sulfate: 0.04%Max

Heavy Metals: 0.0015%Max

Trademark: Pharmlab

Specification: 98.5-101.5%

HS Code: 2922509090

Mf:C9h11no3

MW:181.19

Uses:Pharmaceutical Intermediate

Shipping Method:EMS, DHL, TNT, FedEx, UPS, Hongkong EMS

Trademark:Pharmlab

Indication

Tyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies.

Pharmacodynamics

Tyrosine is a nonessential amino acid synthesized in the body from phenylalanine. Tyrosine is critical for the production of the body's proteins, enzymes and muscle tissue. Tyrosine is a precursor to the neurotransmitters norepinephrine and dopamine. It can act as a mood elevator and an anti-depressant. It may improve memory and increase mental alertness. Tyrosine aids in the production of melanin and plays a critical role in the production of thyroxin (thyroid hormones). Tyrosine deficiencies are manifested by hypothyroidism, low blood pressure and low body temperature. Supplemental tyrosine has been used to reduce stress and combat narcolepsy and chronic fatigue.

Mechanism of action

Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the phenylalanine required goes into the production of tyrosine; if the diet is rich in tyrosine itself, the requirements for phenylalanine are reduced by about 50%. The mechanism of L-tyrosine's antidepressant activity can be accounted for by the precursor role of L-tyrosine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects.

Absorption

L-tyrosine is absorbed from the small intestine by a sodium-dependent active transport process.

Metabolism

In the liver, L-tyrosine is involved in a number of biochemical reactions, including protein synthesis and oxidative catabolic reactions. L-tyrosine that is not metabolized in the liver is distributed via the systemic circulation to the various tissues of the body.

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