Phenacetin White Raw Hormone Powders For Analgesic And Antipyretic , CAS 62-44-2 / Whatsapp:+8615308670259

Basic Info

Name: Phenacetin

Cas NO.:62-44-2

EINECS:200-533-0

Molecular Formula:C10H13NO2

Melting Point:133-138℃

Boiling Point:(dec)

Stability:Stable. Incompatible with strong oxidizing agents, strong acids.

Water Solubility:0.076 g/100 mL

Refractive index:1.505 (20 C)

Flash Point:355.1 °C at 760 mmHg

Purity:99%min

Appearance:white crystalline powder

Usage:Analgesic, antipyretic. Component of APC tablets

Description

The painkiller phenacetin was the world's first synthetic pharmaceutical drug. Phenacetin was often accompanied by aspirin and caffeine in what were called APC pills, which were widely distributed during and after World War II. The use of phenacetin in the U.S. was discontinued in the 1980s because of links to cancer and other adverse side effects, but it remains available in some countries.

Phenacetin is a white crystalline powder with the chemical composition C10H13NO2. It was first developed by Harmon Northrop Morse in 1878. In addition to its pain-reducing properties, it also has been used as a fever-reducer, a treatment for rheumatoid arthritis and a treatment for intercostal neuralgia, a rare disorder that causes pain in the nerves around the ribs. It was one of the first painkillers that was not derived from opium while at the same time being absent of anti-inflammatory qualities.

In 1983, the U.S. Food and Drug Administration (FDA) banned phenacetin in the U.S. because of its discovered carcinogenic properties and its link to kidney failure. The FDA stated that phenacetin alone is reasonably believed to be a human carcinogen, or cancer-causing agent, and that painkiller mixtures containing the drug are known human carcinogens. There has been little evidence found that phenacetin alone is a human carcinogen because it usually has been administered in combination with other drugs.

Application

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)).

Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.]

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