CAS 1379686-29-9 Pharmaceutical Sarms Material Sr9011 for Weight Loss / Whatsapp:+8615308670259

Basic Info

Model NO.: 1379686-29-9

Customized: Non-Customized

Assay: 99%

Appearence: White Powder

MW: 479.03524

Mf: C23h31cln4o3s

Payment: Wu, Money Gram, Bitcoin, Bank Transfer

Delivery Time: Within 24 Hours After Payment

Trademark: Pharmla

HS Code: 2932999099

Powder: Yes

Certification: GMP, USP, BP

Solubility: DMSO up to 100 mM

Storage Powder: 4ºC 1 year

              DMSO: 4ºC 3 month

                        -20ºC 1 year

Flash Point: 261.5 ° C

Einecs Number: 208-116-5

Melting Point: 167-169 ºC

Origin: China

Description

SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates. SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.

SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. 

Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

Application

SR9011 is one of a pair of compounds developed at TSRI by Burris and his team. The drug binds to Rev-erbα,a natural protein in the body that influences lipid and glucose metabolism in the liver, inflammatory responses, and fat-storing cells. By binding to Rev-erbα, SR9011 can kickstart metabolism with another pleasant side-effect: increased muscle strength.

SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.

SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.

SR9009 And SR9011 

The difference between SR9009 and other diet pills is in its chemistry. SR9011 is not an appetite suppressant-as many weight-loss drugs are-and directly works by increasing the metabolic rate of muscle. Your metabolism speeds up and slows down naturally during the day, meaning that sometimes food is used for energy and sometimes it's stored as fat. By re-synching a dysfunctional metabolic clock, SR9011 ensures that food and excess fat are used as energy.

How to Use

In vitro: SR9011 was used at 5-10 µM concentration in vitro and in cellular assays.

In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in

different mouse models.

______________________________ For Your Reference ______________________________

Place of origin : China

Certificate : ISO9001:2008, KOSHER, GMP, SGS

Quality Standard : USP

Minimum Order Quantity : 10 g

Production Capacity    : 1000 Kg/Month

______________________________ Package & Delivery ______________________________

Package : Foil bag, Foil tin , Drum or as your request

Payment Method  : T/T, Western Union, MoneyGram, Bitcoin

Shipping Method : EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC

Leading  time : Within 48 hours after confirming payment

Delivery time : Within 5 working days after confirming payment

______________________________ Why Choose Us ? ______________________________

1. Quality : we deal with steroid relevant products over 15 years, and have many stable customers from all over the world. All of them witness our products' quality.

2. Package : Different package for different customs results in high rate of customs clearance.

3. Delivery: No matter where you are from, safe delivery will be finished within 7 working days.

4. Guarantee: Reship policy will be shown to you before your order. The more you buy, the more discounts you will enjoy.

You Should Know

The products achieve the advanced standard of domestic market, most of which even reach the international standard and conform to the requirements of FCC, USP, EP and BP with high level research group, advanced apparatus and good scientific atmosphere which ensure the stable and reliable quality. Besides, the factory has a complete Q. A. & Q. C. System. We own authorized sets of analyzing instruments that have high efficiency and high sensitivity, such as HPLC, GC and UV spectrophotometer to analyze and control the products. 

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