High Purity Raw Powder Local Anaesthesia Drugs Dibucaine Hydrochloride CAS 61-12-1 for Anti-Paining 

Basic Info

Model NO.: 61-12-1

Suitable for: Adult

Purity: >99%

Product: Dibucaine Hydrochloride

CAS: 61-12-1

Apperence: White Powder

Trademark:  Pharmlab

Specification: USP/EP/BP

HS Code: 3402

Powder: Yes

Certification: ISO 9001, USP, BP

State: Solid

MOQ: 10g

Synonyms: Butoxycinchoninicaciddiethylethylenediamidehydroch

Einecs: 200-498-1

Stroge: in Cool and Dry Condition

Transport Package: Foil Bag/Drum or as your requirement

Origin: China

Product Description

CAS 61-12-1 Local Anaesthesia Drugs Dibucaine Hydrochloride / Dibucaine HCL

Dibucaine hydrochloride

CAS:61-12-1

EINECS number:200-498-1

Molecular formula: C20H31Cl2N3O2

Molecular weight:416.385

MP:99-101 ºC

Boiling point:544.7 ºC at 760 mmHg

Flash Point:283.2 ºC

Vapor Pressure:3.37E-12mmHg at 25 ºC

Properties:

MP 99-101 ºC

Use:Anesthetic (local),Pharmaceutical raw materials

Packing:Foil bag or as requirments

English alias: Dibucaine, Nupercaine, Percaine Sovcaine

Drug categories: local anesthetics

Description:

Dibucaine hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. 

In combination sodium dibucaine hydrochloride is administered to dogs to induce rapid, humane, painless euthanasia. The euthanasia solution is toxic to wildlife. Euthanized animals must be properly disposed of by deep burial, incineration or other method in compliance with state and local laws

Applications:

Spinal anesthesia (high, low, saddle block) and topically to produce surface anesthesia. Eye: To anesthetize conjunctiva and cornea prior to superficial procedures (including tonometry, gonioscopy, removal of foreign bodies or sutures, corneal scraping).

Nose and Throat: To abolish laryngeal and esophageal reflexes prior to bronchoscopy, esophagoscopy.

Skin: To relieve pruritus, pain, burning.

Pharmacological pharmacokinetics

Although the chemical structure of cinnamic acid hydrochloride amide, but still and local anesthetic local esters, plasma cholinesterase can be hydrolyzed, clinically and can be used to identify the effect of the esterase. Local anesthesia than procaine 22 to 25 times, long duration, but the toxicity of procaine than 15-20 times, once poisoning, rescue takes 4-8 hours to reverse.

In the organization than procaine stable, so the duration of anesthesia for a long time (about three times that of procaine).

Indications

For epidural anesthesia and spinal anesthesia. This product is easy through the mucosa, but also for surface anesthesia, but because of its toxicity is too large (about 15 times higher than procaine), less for infiltration anesthesia.

Dosage and Usage

Limited to adult subarachnoid block, generally limited to 10mg, shall not exceed 15-20mg.

Topical dosage forms and their usage and dosage:

1. Cream 0.5%, applied to the skin affected area, each prescription for 24 hours, adult 30mg is limited to children 2.5 ~ 5.0mg.

2. Ointment 1%, for the hemorrhoid coated surface of the lesion, early, late and after a time.

Epidural anesthesia and spinal anesthesia with 0.2-0.25% solution, total 7.5-12mg; surface anesthesia with 0.05-0.2% solution; infiltration anesthesia with 0.01-0.1% solution, the total does not exceed 15mg.

Adverse reactions

Toxicity, may have nausea, sweating, difficulty breathing, delirium or delirium. High-dose use, convulsions, facial or skin flushing. Individual cases of allergic reactions.

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