Fat Loss Polypeptide Hormone Mgf for Growth of Adult Muscle

Quick Details: 

Product Name: MGF

CAS : 12020-86-9

Synonyms: PEG MGF

Sequence: PEG-Tyr-Gln-PRO-PRO-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-NH2

MF: C121H200N42O39

MW: 2888.16

Appearance: White Lyophilized Powder

Function: Promotion Development Dosage

Form: Powder

Active Substance: It is PEGylated MGF. 

Storage :Lyophilized Peg MGF is stable at room temperature for 90 days,however it should be stored in a freezer below -8C for any extended period of time. After reconstituting Peg MGF should be refrigerated at temperatures not to exceed 36 F. 

Description:

MGF 2MG - Mechano Growth Facto

Pegylated Mechano Growth Facto (PEG MGF) is a variant of the IGF-1 (insulin-like growth facto-1), which stimulates myoblasts division and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. The difference between IGF-1 and MGF is that MGF stimulate myoblasts division through stimulation of different receptors.

At early stages, the use of MGF was limited because, once in the body, this drug broke down within a few minutes. But the scientists found an easy and brilliant decision, which was pegylation. A MGF molecule was attached to a polyethylene glycol molecule, which acts as a protective coating and allows MGF to be carried through the blood stream without being broken down without loosing its bioactivity and efficiency.

What is MGF?

MGF (Mechano Growth Factor), also known as IGF-1Ec, is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for the growth of adult muscle. MGF is produced naturally when muscle fibers are broken down through resistance (weight training). MGF stimulates muscle growth, creates new muscle fibers, promotes muscle recovery, promotes nitrogen retention and increases protein synthesis.

In studies where MGF was administered intramuscularly, there was a 20% increase in the weight of the injected muscle fibers within 2 weeks. In further studies, it took 4 months for IGF to cause a 25% increase in muscle mass. MGF was found to be more potent than IGF-1 in rapid muscle growth. Fat loss and strength increases are not typically seen with MGF's use (as they are with IGF-1 use).

How much MGF should be used?

A typical protocol would be:

100-300mcg of MGF divided into 1-2 bilateral administrations in 2-5 different areas of the muscles approximately 5-7 days a week - intramuscular injections.

Example, if you want to administer 200mcg of MGF into the chest and biceps muscles 2 times a day and 3 different areas of the muscle then you would need to divided the dose as follows:

200mcg / 2 times per day = 100mcg per administration

100mcg per administration / 4 muscles (2 chest and 2 bicep muscles) = 25mcg per muscle

25mcg per muscle / 3 different locations on each muscle = 8.3mcg per injection

Theoreticall, the more locations used to administer the MGF into the muscle the more places for muscle growth.

How to reconstitute MGF?

MGF is typically manufactured in 2mg amounts and is reconstituted with sterile water.

If 2ml (2 full - 1 ml U-100 insulin syringe) of sterile water is added to the vial then each unit of the syringe will equal 10mcg.

If the syringe is filled up to 10 units (up to the number 10 on the syringe) it will equal 100mcg of MGF.

How long should MGF be used?

In most studies on MGF no adverse side effects were reported with use for 4-8 weeks (per the dosage limits in the above answer) followed by 4 weeks of non-use.

Effect of MGF :

Asingle intramuscular injection into muscle resulted in a 25% increase in mean muscle fibre cross section area within three weeks.

Using a similar protocol, liver-derived IGF-1 took four months to produce a 15% increase.

It would also appear that with regards to age, the young have a better ability to respond to MGF ,and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.

Action:

 When mechanical overload is introduced to a muscle , the IGFS-1 gene released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGFS-1Ec . This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of IGFS-1 into MGF, production then switches towards producing a systemic release of IGFS-1Ea from the liver, which also upregulates protein synthesis as well.MGF is available as an injectable peptide, and it has been anecdotally shown that injecting it will cause a response in the area resulting in localized muscle growth.

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