Welcome to factory-direct-buy
Hubei Yuancheng Saichuang Technology Co., Ltd
Hubei Yuancheng Saichuang Technology Co., Ltd
Sign in or Join Free Now!

Manufacturer Video

Contact Us

Street Address
496 Zhongshan Road
China (Mainland)/Hubei


Oral High Quality Female Anti-Estrogenic Steroid Chlormadinone Acetate CAS;302-22-7
Oral High Quality Female Anti-Estrogenic Steroid Chlormadinone Acetate CAS;302-22-7
Supply Ability:
0 Gram/Grams per 0
  • Product Detils
  • Company Profile
Quick Details
Place of Origin:
China (Mainland)
Brand Name:
Model Number:
Packaging & Delivery
Disguised package; Foil bag
Product Description

Oral High Quality Female Anti-Estrogenic Steroid Chlormadinone Acetate CAS;302-22-7 


Basic Info

Product Name: Chlormadinone Acetate

Synonyms: 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione;





Suitable for: Elderly, Adult

Purity: >99%

CAS: 302-22-7

Appearance: White Powder

Molecular Formula: C23H29ClO4

Molecular Weight:404.93


Fuction: Female Sex Hormone

Usage: Potent progesterone,Orally active progesteron with antiandrogenic activity; has been used in combinations as an oral contraceptive. Progestogen; antineoplastic (hormonal).

Shipping: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC

Delivery Time: 3-5 Working Days Door to Door

Transport Package: Disguised package; Foil bag

Origin: China

Certification: ISO 9001, USP, GMP

Storage: Cool Dry Place

Payment: Western Union, Money Gram, Bank Transfer, Bitcoin

Reship Policy: Reship for Fee

HS Code: 2937290019


Chlormadinone acetate (CMA) is a derivative of progesterone (17-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961 and is used as an orally effective progestogen in hormone replacement therapy (HRT), and in combination with ethinyl estradiol (EE) in contraception since 1999. Chlormadinone acetate has a strong progestogenic effect about one-third higher than that of progesterone and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT). In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect. No pregnancy-maintaining effect of CMA has been demonstrated in humans.

The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone and the competitive inhibition of 5-reductase. In this respect, dosing of CMA is crucial; agonistic effects are observed when doses are increased from those optimal for an antagonistic effect.

Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients. The clinical and metabolic tolerability of CMA has been demonstrated in numerous clinical studies with duration of treatment of up to 2.5 years.

The more recent application of CMA as an oral contraceptive in combination with EE (Neo Eunomin, Belara) has proven highly successful, with studies reporting excellent contraceptive efficacy, high tolerability and adherence due to a good side effect profile and positive effects on preexisting dysmenorrhea, skin and hair conditions.





CMA acts predominantly as a potent progestogen, but also as an antiandrogen. Due to its potent actions as a progestogen, CMA also has strong antigonadotropic properties, and thus additional antiandrogen as well as antiestrogen properties.




Like other steroidal progestins with antiandrogen properties such as cyproterone acetate, medroxyprogesterone acetate, and megestrol acetate, as well as spironolactone (a steroidal antimineralocorticoid with antiandrogen and progestogen properties), but unlike non-steroidal antiandrogens such as flutamide and bicalutamide, CMA is not a silent antagonist of the androgen receptor (AR) but rather a weak partial agonist of the AR with the capacity to activate the receptor in the absence of more efficacious agonists such as testosterone.




Similarly to other 17α-hydroxyprogesterone derivatives such as cyproterone acetate, medroxyprogesterone acetate, and megestrol acetate, CMA is a weak glucocorticoid, and has the potential to cause adrenal insufficiency upon abrupt discontinuation of the drug at sufficient dosages.


4. 5α-Reductase


Chlormadinone acetate is a competitive inhibitor of 5α-reductase.


Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus. 

Competitive Advantage:

1 High quality with competitive price:

1) Standard: Enterprise Standard

2) All Purity≥98%

3) We are manufacturer and can provide high quality products with factory price.

2 Fast and safe delivery:

1) Parcel can be sent out in 24 hours after payment. Tracking number available

2) Secure and discreet shipment. Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

3 We have clients throughout the world:

1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.

2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility.

3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.


Packaging & Delivery:

1. Professional team for package and shipment.

2. Fast and discreet shipment could be arranged for customs pass Guaranteed.

3. Tracking code 24 hours for customs pass guaranteed.

4. Many kinds of shipment, also can be as your requirement.

Please feel free to contact me, if you have any questions.



Chlormadinone acetate 2.jpg

Send your message to this manufacturer
Your message must be between 20-8000 characters

© 2015 - 2024, wfdbn.com All rights reserved.